The Sample Characteristics dataset includes information on the participants who are included in the studies. This information is provided at the study level—meaning, data are not broken down into the specific treatment arms such as the intervention or control groups. Use this dataset if you want to learn more about the number of participants in the study; inclusion and exclusion criteria related to substance use and suicidality; baseline clinical characteristics such as PTSD severity, trauma type, military status, and comorbidities; and, basic demographic information such as age, gender or race for the sample as a whole (not individual participants). Visualizations made from this dataset will be based on the 496 RCTs included in the PTSD-Repository. Values reported as "NA" or not reported "NR" by the study are null values (empty cells). Data is at the study level.

The Study Characteristics dataset includes basic information about study design. In addition to study class, the dataset includes clinical setting, whether the study looked at PTSD symptom clusters, whether there were any subgroup analyses, type of diagnostic measure used (e.g., diagnostic interview, self-report), and provider credentials. Use this dataset to better understand the variety of RCT designs employed, compare studies by study class or to identify gaps in the literature for potential new RCTs. Visualizations made from this dataset will be based on the 550 RCTs included in the PTSD-Repository. Values reported as "NA" or not reported "NR" by the study are null values (empty cells). Data is at the study level.

Records references to secondary studies and companion publications included with primary studies in the PTSD-Repository.
These secondary, referenced studies may or may not have contributed data to the abstraction of the listed primary study. The relationship of the secondary study to the primary study is described in some cases in the `Secondary Study Relationship` column.

Identifying information about each study, including citation, PubMed ID, PTSDPubs ID, ClinicalTrials.gov ID, and funding source(s).

Check this story often to see a chronological list of important edits, new data, recently published data stories and more.

This document contains brief descriptions of many of the treatments found in the PTSD Repository, organized by treatment category.

Note: The download is a .zip file which contains the PDF Reference Guide.

Learn how risk of bias was included for each study in the PTSD Repository, with a description of domain elements and overall ratings.

Learn about treatments for those who have both PTSD and substance use disorder (SUD).

Learn about studies of trauma-focused psychotherapies, the most effective approach to treating PTSD, found in the PTSD-Repository.

The PTSD-Repository is a comprehensive database of PTSD trials. The PTSD-Repository allows clinical, research, education, and policy stakeholders to understand current research on treatment effectiveness and harms, and enable informed decisions about future research, mental health policy, and clinical care priorities. This report updates the studies and variables included in the PTSD-Repository to include recently published trials, interventions targeting comorbid PTSD/SUD (substance use disorder), variables related to comorbidities such as suicide and SUDs, and risk of bias (ROB) assessment.

The Comparative Effectiveness Review (Update Report) and Evidence Tables (Appendix E, F-1, & G-1) are included in the downloadable .zip file. For more information, visit AHRQ's page, and open the "Previous Versions" tab: https://effectivehealthcare.ahrq.gov/products/ptsd-pharm-non-pharm-treatment/research