This document contains brief descriptions of many of the treatments found in the PTSD Repository, organized by treatment category.

Note: The download is a .zip file which contains the PDF Reference Guide.

Learn about treatments for those who have both PTSD and substance use disorder (SUD).

The PTSD Repository is a useful tool for staying up-to-date with PTSD clinical trials research, to inform your work and to support patient education.

The resources on this page support learning about PTSD and effective treatments, providing treatment, and doing research using PTSD Repository data.

The Study Interventions dataset includes information about each of the specific treatment arms that were studied in all RCTs. Each study arm was coded to indicate the type of intervention or comparison condition. This dataset includes the study-level Study Class as well as individual variables for each category of treatment, coded as Yes or No for each arm. Study arm treatment category variables are as follows: Pharmacotherapy (as well as a subclass such as antidepressant, antianxiety, etc.); Psychotherapy (as well as a subclass to identify trauma-focused or non-trauma-focused therapy); Complementary and Integrative Health (CIH; as well as a subclass such as relaxation or meditation); Nonpharmacologic Biological; Nonpharmacologic Cognitive; Collaborative Care; Other Treatments; Control
The Study Intervention dataset also includes information on the format of the treatment (individual, group, couples, mixed); treatment delivery method (in person, by phone, by video, technology alone, technology assisted, written or mixed); dose or amount of treatment and, treatment completion and adherence. Use this dataset to learn about treatment studies of a particular type

Each record is an arm of the study, labeled as A, B, C, or D. Values abstracted as not applicable ("NA") or not reported ("NR") from the study are null values (empty cells).

Learn how risk of bias was included for each study in the PTSD Repository, with a description of domain elements and overall ratings.

Access an article reviewing the development of the PTSD Repository as well as meta-analyses and journal articles that use PTSD Repository data.

Definitions of abbreviations found throughout the PTSD-Repository.

The Study Characteristics dataset includes basic information about study design. In addition to study class, the dataset includes clinical setting, whether the study looked at PTSD symptom clusters, whether there were any subgroup analyses, type of diagnostic measure used (e.g., diagnostic interview, self-report), and provider credentials. Use this dataset to better understand the variety of RCT designs employed, compare studies by study class or to identify gaps in the literature for potential new RCTs. Visualizations made from this dataset will be based on the 550 RCTs included in the PTSD-Repository. Values reported as "NA" or not reported "NR" by the study are null values (empty cells). Data is at the study level.

The PTSD-Repository is a comprehensive database of PTSD trials. The PTSD-Repository allows clinical, research, education, and policy stakeholders to understand current research on treatment effectiveness and harms, and enable informed decisions about future research, mental health policy, and clinical care priorities. This report updates the studies and variables included in the PTSD-Repository to include recently published trials, interventions targeting comorbid PTSD/SUD (substance use disorder), variables related to comorbidities such as suicide and SUDs, and risk of bias (ROB) assessment.

The Comparative Effectiveness Review (Update Report) and Evidence Tables (Appendix E, F-1, & G-1) are included in the downloadable .zip file. For more information, visit AHRQ's page, and open the "Previous Versions" tab: https://effectivehealthcare.ahrq.gov/products/ptsd-pharm-non-pharm-treatment/research